Beilstein J. Nanotechnol.2016,7, 645–654, doi:10.3762/bjnano.7.57
signaling pathways, dysregulated neurotransmitters and synaptic plasticity have also been shown to contribute to neurotoxicity of TiO2 NPs. Recently, studies on autophagy and DNAmethylation have shed some light on possible mechanisms of nanotoxicity. Therefore, we offer a new perspective that autophagy and
DNAmethylation could contribute to neurotoxicity of TiO2 NPs. Undoubtedly, more studies are needed to test this idea in the future. In short, to fully understand the health threats posed by TiO2 NPs and to improve the bio-safety of TiO2 NPs-based products, the neurotoxicity of TiO2 NPs must be
investigated comprehensively through studying every possible molecular mechanism.
Keywords: autophagy; brain; DNAmethylation; neurotoxicity; titanium dioxide nanoparticles; Introduction
Titanium dioxide nanoparticles, smaller than 1 μm in at least one dimension, possess specific physico-chemical
Beilstein J. Nanotechnol.2014,5, 677–688, doi:10.3762/bjnano.5.80
ICM and trophoblast by cells derived from the injected blastomere will be picked up by a decrease in NANOG and OCT4 expression. DNMT3A performs de-novo DNAmethylation during the reprogramming phase of parental genomes. Therefore, changes in expression would point out interference with epigenetic
responsible for the de-novo DNAmethylation of the embryonic genome). Nevertheless, to further confirm these findings future experiments may additionally include the determination of blastocyst cell numbers, further genetic markers for normal development, like trophectodermal transcripts, and finally embryo
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Figure 1:
Number distribution of nanoparticle size including corresponding TEM micrographs as inserts of (A) ...